TCV-309 chloride
CAS No. 121494-09-5
TCV-309 chloride ( TCV309 chloride;TCV 309 chloride )
Catalog No. M10802 CAS No. 121494-09-5
A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 209 | Get Quote |
|
50MG | 1044 | Get Quote |
|
100MG | 1566 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTCV-309 chloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionA highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
-
DescriptionA highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively; potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively; also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.Coagulation DisorderPhase 2 Discontinued
-
SynonymsTCV309 chloride;TCV 309 chloride
-
PathwayOthers
-
TargetOther Targets
-
RecptorOther Targets
-
Research AreaCardiovascular Disease
-
IndicationCoagulation Disorder
Chemical Information
-
CAS Number121494-09-5
-
Formula Weight629.97
-
Molecular FormulaC30H34BrClN4O4
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 6.3 mg/mL
-
SMILESCCC[N+]1=CC(=CC(=C1)Br)C(=O)N(CCC(=O)NCCOC(=O)N2CCC3=CC=CC=C3C2)C4=CC=CC=C4.[Cl-]
-
Chemical NamePyridinium, 3-bromo-5-[[[3-[[2-[[(3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]oxy]ethyl]amino]-3-oxopropyl]phenylamino]carbonyl]-1-propyl-, chloride (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Terashita Z, et al. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67.
3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67.
3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
molnova catalog
related products
-
Potassium 7-hydroxy-...
Potassium 7-hydroxy-1-naphthalenesulfona is naturally present in the fruit of the Rubiaceae gardenia, the flowers of the Iridaceae crocus, and the flowers and leaves of the Scrophulariaceae Scrophulariaceae.
-
Aegeline
Aegeline is an alkaloidal-amide isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.?
-
Ledipasvir acetone
Ledipasvir (GS5885) is an HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.